Inflammation in Brain Linked to Autism

Maybe a little closer to understanding a bit more about autism…a new study published in Nature Communications is showing that the brains of people with autism share a common pattern of inflammation related to an overactive immune response.

As discussed in this article, researchers from Johns Hopkins and University of Alabama at Birmingham analyzed the data from autopsied brains of 72 people – 32 of whom had autism – and of those that had autism, they found genes for inflammation permanently activated in certain cells. This was the largest ever study of gene expression in autism.

The inflammation is not likely a root cause of autism, but possibly a consequence of a gene mutation. In order to better understand the inflammation’s effects, researchers will need to determine whether treating it will make an impact on symptoms.

As one of the researchers involved in the study points out, the current findings highlights how much we don’t know about the way our immune systems affect brain activity.

 

Lynsey, Community Manager 

100+ Genes Tied to Autism (New Study)

cover_natureSome new research that came out is getting a lot of attention. As we are still without a known cause of autism, this particular research could potentially prove to be a step closer to having a better understanding of what may cause autism.

Two studies were published in Nature that showed dozens of sets of genes are closely connected to the development of autism. As discussed in this article, the research claims that 60 genes are within a ‘high-confidence” threshold—meaning that mutations in those genes are 90% likely to increase the risk of autism. (Previously only 11 genes had been identified with the ‘high-confidence’ threshold.)

It went on to show that these genes appear to be clustering around three sets of biological functions—(1) the development of synapses (which are responsible for communication among nerves); (2) the creation of genetic instructions; and, (3) DNA packaging within cells.

With environmental factors being a possible theory of what may cause autism, this research may now steer scientists more toward genetics.

As with any new research and findings, more investigation is needed – but their initial discovery is very compelling.

Read more about this study here.

Lynsey, Community Manager